{"id":5392,"date":"2025-10-21T23:42:27","date_gmt":"2025-10-21T20:42:27","guid":{"rendered":"https:\/\/ophthalmogen.com\/?p=5392"},"modified":"2026-01-13T18:03:44","modified_gmt":"2026-01-13T16:03:44","slug":"xalazio-kai-ormoniki-isorropia-apo-tin-efiveia-ews-tin-emminopafsi","status":"publish","type":"post","link":"https:\/\/ophthalmogen.com\/en\/2025\/10\/21\/xalazio-kai-ormoniki-isorropia-apo-tin-efiveia-ews-tin-emminopafsi\/","title":{"rendered":"Chalazion and Hormonal Balance \u2013 From Puberty to Menopause"},"content":{"rendered":"
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How hormonal fluctuations influence eyelid health and Meibomian gland function.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Since ancient times, Greek physicians \u2014 from Hippocrates to Galen \u2014 associated the balance of the body\u2019s internal \u201chumors\u201d with the health of the skin and eyes.
Today, this timeless wisdom is reborn through Dermophthalmology, which shows that hormonal changes directly affect the function of the Meibomian glands and the likelihood of developing a chalazion.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Historical Note<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tThe term \u201cchalazion\u201d (from the Greek \u201c\u03c7\u03ac\u03bb\u03b1\u03b6\u03b1\u201d, meaning \u201csmall lump or grain\u201d) entered medical vocabulary in the 19th century, when Heinrich Meibom first described the sebaceous glands that produce the lipid layer of the tear film.\nBy the early 20th century, ophthalmologists had already observed that women experienced more recurrent chalaziaduring hormonal transitions such as puberty, pregnancy, and menopause.\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Hormones and the Meibomian Glands<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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The Meibomian glands are androgen-dependent, meaning their function is regulated by hormones such as testosterone and estrogen.
Androgens<\/b>
\u2022\tIncrease lipid production and maintain meibum fluidity.
\u2022\tDecreased levels (e.g., in menopause or after hormonal therapy) lead to thicker secretions and gland obstruction.
Estrogens<\/b>
\u2022\tAffect epithelial health and lipid balance.
\u2022\tTheir decline after age 40 is linked to dryness, inflammation, and chalazion formation.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Clinical Evidence<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tRecent ophthalmologic and endocrinologic studies (Harvard Eye Research Institute, Tokyo Women\u2019s University, 2019\u20132023) confirm that:\n\u2022\tWomen aged 35\u201355 have twice the risk of developing chalazia compared to men of the same age.\n\u2022\tMeibomian Gland Dysfunction (MGD) exhibits a clear hormonal profile, characterized by low DHEA and androgen levels.\n\u2022\tHormone Replacement Therapy (HRT) may improve tear film stability but must be individualized to avoid lipid overproduction.\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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The Holistic Perspective \u2013 From Puberty to Menopause<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Dermophthalmology proposes a multidisciplinary framework that integrates:
\u2022Ophthalmology \u2013 Meibomian gland function
\u2022Dermatology \u2013 Sebaceous secretion and skin pH
\u2022Endocrinology \u2013 Hormonal cycles and balance
\u2022Nutrition Science \u2013 Omega-3s, lignans, and antioxidants<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Supporting Hormonal Balance Naturally<\/strong><\/p>